Official website of GRiPPA - Research Group for the Prevention of Environmental Disease - edited by Giancarlo Ugazio

Gruppo di Ricerca per la Prevenzione

della Patologia Ambientale

Research Group for the Prevention of Environmental Disease

Italiano

DYNAMICS  OF  ENVIRONMENTAL  DISEASE  THROUGHOUT  MAN'S  LIFESPAN



 

CD-6

ACCELERATED PROGRESSION FOR TOXICOLOGICAL POTENTIATION:

EARLY POINT OF NO RETURN, SHORTENED LIFE EXPECTANCY

POST-NATAL EXPOSURE, FOR ALL THE LIFESPAN:

CONTENT

01

ACCELERATED PROGRESSION FOR ENZYMATIC AND TOXICOLOGICAL POTENTIATION (overall picture)

02

EXPOSURE TO  AGENTS ACTING ON THE ENZYMATIC SYSTEM WHICH METABOLISE XENOBIOTICS

03

CLINICAL SIGNS OF INDUCTION: HEPATOMEGALIA, ENHANCED TOLERANCE TO ALCOHOL, SHORT NARCOTIC EFFECTS OF BARBITURATES

04

POSITIVITY OF BIOLOGICAL EXPOSURE WITHIN NORMAL LIMITS

05

POSITIVITY OF BIOLOGICAL DAMAGE INDICATORS EARLIER THAN EXPECTED

06

EARLY APPEARANCE OF IRREVERSIBLE SYMPTOMS AND OF THE POINT OF  NO RETURN (e.g. cirrhosis of the liver)  AND EARLY DECLINE IN THE  QUALITY OF LIFE

07

LIFE EXPECTANCY NOT REACHED, (BEFORE 76 FOR MEN AND 82 FOR WOMEN) WITH EARLY DEATH

 

 
 

Summary

  When humans are exposed to compounds which are not in themselves true poisons but precursors of harmful agents, there is the risk of setting off those enzymatic systems which nature has provided as defence systems against intrusive biotics. This has helped in the past, since man first appeared on the earth along with many other animal species with whom he shares environmental risks. This entailed the adaptation to the environment based on slow, natural rhythms: now all this has changed after the industrial revolution and the technological progress and biomedical and scientific advance it brought. Today things are radically different, we are speaking about molecules and environmental conditions which our ancestors, the ancient Romans and Greeks could have never dreamed of existing. To be honest Imperial Rome polluted the world with the heavy metals which were used in those times, above all lead, and was to fall victim to lead poisoning, in its various clinical forms.

But today, in addition to the elements which cause direct damage to our organism, we have to face a host of recently invented compounds which are used in various industrial sectors. Man has created a list of intrusive biotics which grows by the day. And it with these precious and perverse new chemical discoveries that we must do our reckoning, especially regarding the toxicological potentiation risks based on enzymatic induction. The final result is an alteration in life pattern which cannot be considered an adaptation, in the positive sense of this term: on the contrary it implies a drop in the quality of life and a shortening of life expectancy where scientific progress has guaranteed a theoretical increase in life expectancy.

Common sense should advise both the man in the street and the scientist to acquire the maximum awareness of these environmental risks if we do not wish to leave future generations an unliveable destiny, rather like the one which saw the extinction of the people of Imperial Rome. Form history we learn that it was replaced by the Barbarians who arrived from distant lands: Visigoths, Ostrogoths, Huns, Longobards and so on, maybe infested with parasites, but mentally sane and fertile.

 

 

 

 

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